CARD8 (caspase recruitment domain family, member 8)
نویسندگان
چکیده
منابع مشابه
CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.
Caspase-associated recruitment domains (CARD) are protein-protein interaction modules found extensively in proteins that play important roles in apoptosis, NFkappaB activation, and cytokine regulation. In this study we identified a novel human protein, CARD-8, which contains a C-terminal CARD domain with high similarity to the CARD domain of caspase-1/ICE. We demonstrate that CARD-8 interacts p...
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Over the last three years, increasing numbers of adaptor molecules that contain the caspase recruitment domain (CARD) have been identified. CARD was originally described as a protein-binding motif that interacts with caspase through a CARD-CARD interaction. However, CARD has now also been found in many adaptor proteins that do not interact with caspase, but mediate the assembly of CARD-containi...
متن کاملExpression Quantitative Trait Loci for CARD8 Contributes to Risk of Two Infection-Related Cancers—Hepatocellular Carcinoma and Cervical Cancer
Caspase recruitment domain family, member 8 (CARD8) can coordinate innate and adaptive immune responses and sensitize cells to apoptosis, which may participate in tumorigenesis of virus-induced hepatocellular carcinoma (HCC) and cervical cancer. By bioinformatics analyses, we identified several single nucleotide polymorphisms (SNPs) within a new identified long non-coding RNA (lncRNA) as expres...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2008
ISSN: 1768-3262
DOI: 10.4267/2042/16963